[mod_python] Difference between run the web service standalone and via mod_python

hi everyone!
some excellent python web framework has its own web-service instance,Just
like Quixote & Djanso, that means we can run our web service without Apache
etc.
so could anybody tell me what's the difference between these modes:1,run the
service standalone of the python web framework 2,attach the python web app
to Apache via mod_python..
thank u!
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