[mod_python] making mod_python.publisher handle every file request

>Use SetHandler:
>
>    <Directory  /some/dir>
>        SetHandler mod_python
>        PythonHandler YOUR-HANDLER
>    </Directory>
Is it possible to do the same thing with mod_python.publisher? because
my <Directory> looks like this at the moment:
    <Directory /var/www/asc/>
        Options Indexes
        AddHandler python-program .py
        PythonHandler mod_python.publisher
        AllowOverride FileInfo
        Order allow,deny
        Allow from all
    </Directory>